PW01-031 – Treatment of FMF in middle and old age
نویسنده
چکیده
Introduction Current recommendations for the treatment of familial Mediterranean fever (FMF) are based largely on the observation of FMF patients receiving colchicine therapy in childhood and young age. The adequate colchicine therapy led to more and more patients survive to that age. In addition, there are national peculiarities of FMF. For example, in Armenia, even before the massive use of colchicine therapy, many patients survived to middle and old age.
منابع مشابه
PW01-022 – Dissociation between CRP and SAA in FMF
Methods CRP and SAA were systematically measured during the follow-up of consecutive attack-free FMF outpatients seen in a pediatric and an adult French reference center. Dissociations between CRP and SAA were defined by normal CRP (<5mg/L) and elevated SAA (group A), or elevated CRP and normal SAA (<10mg/L) (group B). Demographic data, genotype, clinical characteristics of FMF, and treatment w...
متن کاملPW01-015 – Canakinumab in adults with colchicin resistant FMF
Introduction Familial Mediterranean fever (FMF) is associated with variations in the MEFV gene resulting in proteolytic activation of IL-1b through the inflammasome complex. There is no established treatment available for those resistant or intolerant to standard of care colchicine treatment. Canakinumab, a fully human selective anti-IL-1b monoclonal antibody with a half-life of ~4-weeks binds ...
متن کاملPW01-007 – Colchicine brand switching in FMF patients
Introduction In July of 2009 the U.S. Food and Drug Administration enacted new regulation of colchicine under the “Unapproved Drugs Program.” Like other old drugs that were on the market before the existence of the FDA, colchicine had never been subjected to FDA-required safety and efficacy trials. One company elected to put colchicine through the FDA’s approval protocol and when approval was g...
متن کاملPW01-024 – Phenotypic analysis of a MEFV negative FMF cohort
Introduction Familial Mediterranean fever (FMF) is an inherited autosomal recessive disorder, ethnically restricted and commonly found among individuals of Mediterranean descent, caused by MEditerranean FeVer gene (MEFV) mutations on the chromosome 16. It is the most frequent periodic febrile syndrome among autoinflammatory syndromes. Eighty % of patients with FMF have MEFV mutations, while aro...
متن کاملPW01-028 – Developing a new severity score for FMF
Introduction Severity is a basic feature that defines the prognosis of a disease. FMF presents with a variety of clinic and laboratory manifestations affecting severity, and evaluation of prognosis is an elusive task. Different severity scores have been previously proposed for FMF, and commonly used ones include Mor, Pras and Tel Hashomer severity scores however recent studies showed that there...
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عنوان ژورنال:
دوره 11 شماره
صفحات -
تاریخ انتشار 2013